Dr. Sakkubai Naidu has initiated a Placebo controlled drug trial of Dextromethorphan(DM) in children with Rett syndrome. It has been shown that a brain chemical glutamate and its receptor (NMDA) are markedly increased in the brain of young Rett patients. This increase has a neurotoxic effect that may be responsible for causing seizures, behavior problems and learning disability in these children. DM is a commonly used cough syrup available over the counter and this blinded study proposes to determine if DM can block the NMDA receptors in the brain to ameliorate the symptoms of Rett syndrome compared to the placebo.

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